通过 MS 分析阐明了药用相关金化合物与硫氧还蛋白还原酶 C 端基序的反应。
Reactions of medicinally relevant gold compounds with the C-terminal motif of thioredoxin reductase elucidated by MS analysis.
机构信息
Laboratory of Peptide & Protein Chemistry & Biology, Department of Chemistry "Ugo Schiff", University of Florence, Via della Lastruccia 13, 50019 Sesto Fiorentino, Firenze, Italy.
出版信息
Chem Commun (Camb). 2010 Oct 7;46(37):7001-3. doi: 10.1039/c0cc01465f. Epub 2010 Aug 23.
The tetrapeptide Ac-Gly-[Cys-Sec]-Gly-NH(2), reproducing the C-terminal motif of the selenoenzyme thioredoxin reductase, was designed and synthesized, and its reactions with a few medicinally relevant gold(i,iii) compounds investigated by ESI-MS. Remarkably, the main reaction products could be unambiguously identified providing valuable insight into the likely mechanisms of enzyme inhibition by gold compounds.
设计并合成了四肽 Ac-Gly-[Cys-Sec]-Gly-NH(2)，其重现了硒酶硫氧还蛋白还原酶的 C 末端基序，并通过 ESI-MS 研究了其与一些有医学相关性的金（i，iii）化合物的反应。值得注意的是，可以明确鉴定出主要的反应产物，这为深入了解金化合物抑制酶的可能机制提供了有价值的见解。
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