非对称环扩张的去对称化：具有α-氢的 7 元环β-酮羰基化合物的立体选择性合成。
Desymmetrizing asymmetric ring expansion: stereoselective synthesis of 7-membered cyclic beta-keto carbonyl compounds with an alpha-hydrogen.
机构信息
Department of Chemistry, Graduate School of Science, Kyoto University, Sakyo, Kyoto, 606-8502, Japan.
出版信息
Chem Commun (Camb). 2010 Sep 28;46(36):6810-2. doi: 10.1039/c0cc01424a. Epub 2010 Aug 23.
PMID:20730222
Abstract
Ring expansion of symmetrically substituted cyclohexanones with N-alpha-diazoacetyl camphorsultam was devised as a stereoselective pathway to the functionalized 7-membered cyclic beta-keto carbonyls having a kinetically stabilized alpha-hydrogen.
摘要
设计了用 N-重氮乙酰基樟脑磺酰胺对对称取代的环己酮进行环扩张，作为一种立体选择性途径来合成具有动力学稳定的α-氢的官能化的 7 元环β-酮羰基化合物。
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