血管紧张素转换酶基因变异及其水平：南印度人群心肌梗死的危险因素。
Angiotensin-converting enzyme gene variant and its levels: risk factors for myocardial infarction in a South Indian population.
机构信息
Institute of Genetics and Hospital for Genetic Diseases, Osmania University, Begumpet, Hyderabad 500016, Andhra Pradesh, India.
出版信息
Singapore Med J. 2010 Jul;51(7):576-81.
INTRODUCTION
Recently, there has been increasing evidence that genetic variation in the angiotensin-converting enzyme (ACE) plays an important role in myocardial infarction. Therefore, the present study was carried out with the aim of investigating the association of the ACE gene insertion/deletion (I /D) polymorphism and its levels in myocardial infarction patients and their first-degree relatives (FDRs).
METHODS
206 patients with myocardial infarction, 168 FDRs and 210 control subjects were enrolled in the study. ACE I /D polymorphism was determined using the polymerase chain reaction method. Serum ACE levels were measured using the photometric method.
RESULTS
The DD genotype and ACE activity were significantly higher in patients (p-value is 0.00006 and 0.0001, respectively) and FDRs (p-value is 0.003 and 0.04, respectively) compared with the controls.
CONCLUSION
ACE DD genotype and ACE levels are important risk factors for myocardial infarction. This study indicates that the higher frequency of the DD genotype and ACE levels observed in FDRs may increase susceptibility to developing myocardial infarction.
介绍
最近有越来越多的证据表明，血管紧张素转换酶（ACE）的基因变异在心肌梗死中起着重要作用。因此，本研究旨在探讨 ACE 基因插入/缺失（I / D）多态性及其在心肌梗死患者及其一级亲属（FDR）中的水平与心肌梗死的关系。
方法
本研究纳入了 206 名心肌梗死患者、168 名 FDR 和 210 名对照者。采用聚合酶链反应法检测 ACE I / D 多态性，采用比色法测定血清 ACE 水平。
结果
与对照组相比，DD 基因型和 ACE 活性在患者（p 值分别为 0.00006 和 0.0001）和 FDR（p 值分别为 0.003 和 0.04）中显著升高。
结论
ACE DD 基因型和 ACE 水平是心肌梗死的重要危险因素。本研究表明，FDR 中观察到的 DD 基因型和 ACE 水平较高可能会增加发生心肌梗死的易感性。
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