Bösel Julian, Amiri Hemasse
University Hospital Heidelberg, Department of Neurology, Im Neuenheimer Feld 400, D-69120 Heidelberg, Germany.
Curr Opin Investig Drugs. 2010 Sep;11(9):1015-24.
Cardiovascular and cerebrovascular diseases share many pathophysiological traits, often impact one another and share several risk factors, though not always to the same magnitude. Therefore, it is not surprising that many classes of cardiovascular drugs have demonstrated effectiveness in the primary prevention, acute treatment and secondary prevention of stroke. Important advances have been made since 2007 in the use of antiplatelets, anticoagulants, antihypertensives, antiarrhythmics and statins for the treatment of stroke. This review summarizes selected clinical trials of cardiovascular drugs completed from 2007 to 2010 that generated important evidence supporting the efficacy of these drugs in stroke treatment. Ongoing trials and preclinical research of promising agents and treatment strategies are also discussed.
心血管疾病和脑血管疾病具有许多共同的病理生理特征，它们常常相互影响，且有若干共同的危险因素，尽管其影响程度并不总是相同。因此，许多类心血管药物在中风的一级预防、急性治疗及二级预防中显示出有效性也就不足为奇了。自2007年以来，在使用抗血小板药物、抗凝剂、抗高血压药、抗心律失常药及他汀类药物治疗中风方面取得了重要进展。本综述总结了2007年至2010年期间完成的心血管药物的部分临床试验，这些试验产生了支持这些药物在中风治疗中疗效的重要证据。文中还讨论了正在进行的试验以及有前景的药物和治疗策略的临床前研究。
