Probing the micelle-bound aggregation-prone state of α-synuclein with (19)F NMR spectroscopy.
作者信息
Wang Gui-Fang, Li Conggang, Pielak Gary J
机构信息
Department of Chemistry, University of North Carolina, Chapel Hill, NC 27599, USA.
出版信息
Chembiochem. 2010 Sep 24;11(14):1993-6. doi: 10.1002/cbic.201000405.
Abstract
摘要
相似文献
1
Probing the micelle-bound aggregation-prone state of α-synuclein with (19)F NMR spectroscopy.利用（19）F核磁共振光谱法探究与胶束结合的易聚集状态的α-突触核蛋白。
Chembiochem. 2010 Sep 24;11(14):1993-6. doi: 10.1002/cbic.201000405.
2
Structure and dynamics of the extended-helix state of alpha-synuclein: Intrinsic lability of the linker region.α-突触核蛋白延伸螺旋状态的结构与动力学：连接区的固有不稳定性。
Protein Sci. 2018 Jul;27(7):1314-1324. doi: 10.1002/pro.3426.
3
Structural characterization of alpha-synuclein in an aggregation prone state.处于易于聚集状态的α-突触核蛋白的结构表征
Protein Sci. 2009 Sep;18(9):1840-6. doi: 10.1002/pro.194.
4
Probing Structural Changes in Alpha-Synuclein by Nuclear Magnetic Resonance Spectroscopy.利用核磁共振光谱探究α-突触核蛋白的结构变化
Methods Mol Biol. 2019;1948:157-181. doi: 10.1007/978-1-4939-9124-2_13.
5
NMR mapping of copper binding sites in alpha-synuclein.α-突触核蛋白中铜结合位点的核磁共振图谱分析
Biochim Biophys Acta. 2006 Jan;1764(1):5-12. doi: 10.1016/j.bbapap.2005.11.003. Epub 2005 Nov 28.
6
Salient Features of Monomeric Alpha-Synuclein Revealed by NMR Spectroscopy.单体 α-突触核蛋白的 NMR 光谱学研究特征。
Biomolecules. 2020 Mar 10;10(3):428. doi: 10.3390/biom10030428.
7
Effect of pseudorepeat rearrangement on alpha-synuclein misfolding, vesicle binding, and micelle binding.假重复重排对α-突触核蛋白错误折叠、囊泡结合及胶束结合的影响。
J Mol Biol. 2009 Jul 17;390(3):516-29. doi: 10.1016/j.jmb.2009.05.058. Epub 2009 May 27.
8
19F NMR studies of α-synuclein-membrane interactions.19F NMR 研究α-突触核蛋白与膜的相互作用。
Protein Sci. 2010 Sep;19(9):1686-91. doi: 10.1002/pro.449.
9
Solid-state NMR reveals structural differences between fibrils of wild-type and disease-related A53T mutant alpha-synuclein.固态核磁共振揭示野生型和疾病相关A53T突变体α-突触核蛋白原纤维之间的结构差异。
J Mol Biol. 2008 Jul 11;380(3):444-50. doi: 10.1016/j.jmb.2008.05.026. Epub 2008 May 17.
10
NMR determination of pKa values in α-synuclein.NMR 测定α-突触核蛋白的 pKa 值。
Protein Sci. 2011 Feb;20(2):256-69. doi: 10.1002/pro.556. Epub 2010 Dec 13.
引用本文的文献
1
F NMR as a tool in chemical biology.F核磁共振作为化学生物学中的一种工具。
Beilstein J Org Chem. 2021 Jan 28;17:293-318. doi: 10.3762/bjoc.17.28. eCollection 2021.
2
Protein F-labeling using transglutaminase for the NMR study of intermolecular interactions.使用转谷氨酰胺酶进行蛋白质F标记用于分子间相互作用的核磁共振研究。
J Biomol NMR. 2017 Aug;68(4):271-279. doi: 10.1007/s10858-017-0125-6. Epub 2017 Jul 29.
3
Simultaneous detection of distinct ubiquitin chain topologies by 19F NMR.通过19F核磁共振同时检测不同的泛素链拓扑结构
ACS Chem Biol. 2014 Oct 17;9(10):2229-36. doi: 10.1021/cb500589c. Epub 2014 Aug 22.
4
Resolution of oligomeric species during the aggregation of Aβ1-40 using (19)F NMR.使用（19）F NMR 解析 Aβ1-40 聚集过程中的低聚体物种。
Biochemistry. 2013 Mar 19;52(11):1903-12. doi: 10.1021/bi400027y. Epub 2013 Mar 8.
5
5-fluoro-D,L-tryptophan as a dual NMR and fluorescent probe of α-synuclein.5-氟-D,L-色氨酸作为α-突触核蛋白的双功能核磁共振和荧光探针
Methods Mol Biol. 2012;895:197-209. doi: 10.1007/978-1-61779-927-3_14.
6
Interaction of α-synuclein and a cell penetrating fusion peptide with higher eukaryotic cell membranes assessed by ¹⁹F NMR.通过 ¹⁹F NMR 评估 α-突触核蛋白和穿透细胞融合肽与高等真核细胞膜的相互作用。
Mol Pharm. 2012 Apr 2;9(4):1024-9. doi: 10.1021/mp200615m. Epub 2012 Mar 13.
本文引用的文献
1
Characterization of RNA invasion by (19)F NMR spectroscopy.利用 (19)F NMR 光谱学对 RNA 入侵进行表征。
J Am Chem Soc. 2010 Jun 30;132(25):8560-2. doi: 10.1021/ja1014629.
2
Detection of transient interchain interactions in the intrinsically disordered protein alpha-synuclein by NMR paramagnetic relaxation enhancement.通过 NMR (paramagnetic relaxation enhancement) 检测在无规卷曲蛋白 alpha-synuclein 中瞬时的链间相互作用。
J Am Chem Soc. 2010 Apr 28;132(16):5546-7. doi: 10.1021/ja9105495.
3
Protein (19)F NMR in Escherichia coli.大肠杆菌中的蛋白（19）F NMR。
J Am Chem Soc. 2010 Jan 13;132(1):321-7. doi: 10.1021/ja907966n.
4
Differential phospholipid binding of alpha-synuclein variants implicated in Parkinson's disease revealed by solution NMR spectroscopy.通过溶液 NMR 光谱学揭示帕金森病相关的α-突触核蛋白变体的差异磷脂结合。
Biochemistry. 2010 Feb 9;49(5):862-71. doi: 10.1021/bi901723p.
5
5-Fluoro pyrimidines: labels to probe DNA and RNA secondary structures by 1D 19F NMR spectroscopy.5-氟嘧啶类化合物：通过 1D 19F NMR 光谱探测 DNA 和 RNA 二级结构的标签。
Nucleic Acids Res. 2009 Dec;37(22):7728-40. doi: 10.1093/nar/gkp862.
6
19F NMR studies of alpha-synuclein conformation and fibrillation.α-突触核蛋白构象与纤维化的19F核磁共振研究。
Biochemistry. 2009 Sep 15;48(36):8578-84. doi: 10.1021/bi900872p.
7
Multiple tight phospholipid-binding modes of alpha-synuclein revealed by solution NMR spectroscopy.溶液核磁共振波谱揭示α-突触核蛋白的多种紧密磷脂结合模式
J Mol Biol. 2009 Jul 24;390(4):775-90. doi: 10.1016/j.jmb.2009.05.066. Epub 2009 May 27.
8
Interplay of alpha-synuclein binding and conformational switching probed by single-molecule fluorescence.通过单分子荧光探测α-突触核蛋白结合与构象转换的相互作用
Proc Natl Acad Sci U S A. 2009 Apr 7;106(14):5645-50. doi: 10.1073/pnas.0809232106. Epub 2009 Mar 17.
9
Single-molecule FRET reveals structural heterogeneity of SDS-bound alpha-synuclein.单分子荧光共振能量转移揭示了与十二烷基硫酸钠结合的α-突触核蛋白的结构异质性。
Chembiochem. 2009 Feb 13;10(3):436-9. doi: 10.1002/cbic.200800644.
10
19F NMR spectroscopy for the analysis of RNA secondary structure populations.用于分析RNA二级结构群体的19F核磁共振光谱法。
J Am Chem Soc. 2008 Dec 24;130(51):17230-1. doi: 10.1021/ja806716s.
Zotero 插件