Lazarchick J, Russell R, Horn B
Department of Pathology/Laboratory Medicine, Medical University of South Carolina, Charleston 29425.
Ann Clin Lab Sci. 1990 Nov-Dec;20(6):373-8.
Anti-thymocyte globulin is strongly reactive with platelets as measured by flow cytometric analysis. This reactivity appears to be independent of human leukocyte antigen (HLA) phenotype, is dose-dependent with saturation of platelet binding sites readily achieved with concentrations of horse anti-thymocyte globulin (ATG) at 0.25 mg per ml, and cannot be blocked with human anti-PLA1 antibody nor with heat-aggregated human IgG. Results of immunoblot studies after electrophoresis of platelet membrane proteins are consistent with the proposal that horse ATG contains antibodies specific for platelet glycoproteins V and IIa.
通过流式细胞术分析测定，抗胸腺细胞球蛋白与血小板有强烈反应。这种反应性似乎与人白细胞抗原（HLA）表型无关，呈剂量依赖性，每毫升0.25毫克的马抗胸腺细胞球蛋白（ATG）浓度很容易使血小板结合位点饱和，并且不能被人抗PLA1抗体或热聚集的人IgG阻断。血小板膜蛋白电泳后的免疫印迹研究结果与以下提议一致，即马ATG含有针对血小板糖蛋白V和IIa的特异性抗体。
