五价砷在人转化细胞系HeLa S(3)和Hep G(2)中的细胞摄取与生物转化
Cellular uptake and biotransformation of arsenic V in transformed human cell lines HeLa S(3) and Hep G(2).
作者信息
Peel A E, Brice A, Marzin D, Erb F
机构信息
Département de Toxicologie-Hydrologie-Hygiène, Faculté de Pharmacie, 3 rue du Professeur Laguesse, 59045 Lille, France.
出版信息
Toxicol In Vitro. 1991;5(2):165-8. doi: 10.1016/0887-2333(91)90037-e.
The biotransformation of arsenate was studied in two human transformed cell lines (epithelial HeLa S(3) and hepatoma Hep G(2) cells) by the determination of several arsenic species both in the culture medium and in the cells. Arsenate reduction, which was observed in the two cell lines, was higher in Hep G(2) cells. Methylation appeared to be a minor pathway for HeLa cells, but was more important in the hepatoma cells.
通过测定培养基和细胞中的几种砷形态，在两种人转化细胞系（上皮性HeLa S(3)细胞和肝癌Hep G(2)细胞）中研究了砷酸盐的生物转化。在这两种细胞系中均观察到了砷酸盐还原现象，在Hep G(2)细胞中更为明显。甲基化似乎是HeLa细胞的一条次要途径，但在肝癌细胞中更为重要。
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