药物治疗：发病机制和新兴治疗方法的概念。炎症性关节炎临床试验设计的挑战。

Pharmacotherapy: concepts of pathogenesis and emerging treatments. Challenges in clinical trial design in inflammatory arthritis.

机构信息

Department of Internal Medicine, University of Nebraska Medical Center, Omaha, Nebraska 68198-3025, USA.

出版信息

Best Pract Res Clin Rheumatol. 2010 Aug;24(4):457-61. doi: 10.1016/j.berh.2009.11.008.

DOI:10.1016/j.berh.2009.11.008

PMID:20732644

Abstract

The prognosis for patients with rheumatoid arthritis has improved dramatically, thanks in large part to many new therapies and therapeutic approaches. Paradoxically, this has created problems for rheumatologists since clinically useful information from appropriate clinical trials has not kept pace with all the new therapeutic options. Essentially, rheumatologists now have many more therapeutic options than they know what to do with. This article discusses why we are in this situation and suggests opportunities to move forward.

摘要

由于许多新的治疗方法和治疗方法的出现，类风湿关节炎患者的预后有了显著改善。矛盾的是，这给风湿病学家带来了问题，因为适当的临床试验提供的临床有用信息并没有跟上所有新的治疗选择的步伐。从本质上讲，风湿病学家现在有了比他们知道如何处理的更多的治疗选择。本文讨论了我们为什么会处于这种情况，并提出了前进的机会。