Institute for Experimental Musculoskeletal Medicine, University Hospital Muenster, Domagkstrasse 3, D-48149 Münster, Germany.
Best Pract Res Clin Rheumatol. 2010 Aug;24(4):527-40. doi: 10.1016/j.berh.2010.02.002.
The Identification of key players of inflammation and pathologic immune response in rheumatoid arthritis (RA) has resulted in the development of novel therapeutic strategies revolutionising the treatment of disease. However, these new therapeutics only indirectly affect the mesenchymal compartment of the inflamed synovium and, in particular, the specific phenotype of activated fibroblast-like cells. These cells have been demonstrated to trigger not only the progressive destruction of articular cartilage and bone but also the switch from acute to chronic inflammation. Therefore, targeting of this population of fibroblast-like cells may provide interesting opportunities to go beyond the mere inhibition of inflammation and to interfere with key disease processes in RA. This review summarises our current knowledge on the role of fibroblast-like cells in RA and points to potentials ways of modulating their disease-specific activation.
类风湿关节炎（RA）中炎症和病理性免疫反应的关键参与者的鉴定导致了新的治疗策略的发展，从而彻底改变了疾病的治疗方法。然而，这些新的治疗方法仅间接影响炎症滑膜的间充质部分，特别是激活的成纤维细胞样细胞的特定表型。这些细胞已被证明不仅会引发关节软骨和骨的进行性破坏，还会引发急性炎症向慢性炎症的转变。因此，针对这群成纤维细胞样细胞可能为超越单纯抑制炎症并干预 RA 中的关键疾病进程提供了有趣的机会。这篇综述总结了我们目前对 RA 中成纤维细胞样细胞作用的认识，并指出了调节其疾病特异性激活的潜在方法。
