Roullet P, Lassalle J M
Laboratoire d'Ethologie et de Psychophysiologie, UFR Sciences et Techniques, Tours, France.
Behav Brain Res. 1990 Dec 7;41(1):61-70. doi: 10.1016/0166-4328(90)90054-i.
It is now well established that variation in hippocampal circuitry correlates with various behavioural measures. In order to formulate more precise hypotheses about the functional role of the supra (SP-MF) and intra-infra mossy fibres (IIP-MF) layers, we investigated their covariation with a large number of behavioural measures in the classic and the spatial open-field taken from a genetically heterogeneous population composed of subjects from 12 isogenic mice groups (9 inbred strains and 3 F1's). The hippocampus-behaviour intercorrelation matrix reveals that behavioural reactions and inferred psychological processes only correlate with IIP-MF. Detailed analysis of correlates shows that IIP-MF positively correlate with locomotor activity, rearings and central sector crossings in the classic open-field and correlate negatively with the short-term habituation index to the objects in the spatial open-field. Surprisingly the memory of the spatial arrangement of a set of objects does not correlate with any hippocampal measure.
现已充分证实，海马体神经回路的变化与各种行为指标相关。为了对超（SP-MF）和内-外苔藓纤维（IIP-MF）层的功能作用提出更精确的假设，我们研究了它们与来自12个同基因小鼠组（9个近交系和3个F1代）的遗传异质群体在经典和空间旷场中的大量行为指标的协变关系。海马体-行为相互关联矩阵显示，行为反应和推断出的心理过程仅与IIP-MF相关。对相关性的详细分析表明，IIP-MF与经典旷场中的运动活动、竖毛行为和中央区域穿越呈正相关，与空间旷场中对物体的短期习惯化指数呈负相关。令人惊讶的是，一组物体空间排列的记忆与任何海马体指标均无关联。
