Department of Radiology, University Hospitals Leuven, Leuven, Belgium.
Prenat Diagn. 2010 Nov;30(11):1044-8. doi: 10.1002/pd.2607.
The aim of this study is to provide reference values for normal fetal kidney growth based on magnetic resonance (MR) volumetry. Differences in side and gender will be investigated.
The institute's database was reviewed for all fetal MR examinations of singleton pregnancies performed between January 2003 and December 2009. Exclusion criteria for renal volumetry were presence of urogenital anomalies, intrauterine growth retardation, polymalformative disorders, oligo- or anhydramnios and maternal diabetes. On anatomical images, renal volumetry was evaluated by delineating kidneys on all slices and combining these into one volume measurement per kidney. Polynomial regression analysis was performed to examine volume evolution over gestational age (GA).
Bilateral renal volumes of 274 MR examinations in 240 fetuses with GAs between 20 and 37 weeks were calculated. The renal volumes strongly correlated with GA (polynomial regression analysis, p < 0.001). No significant difference could be observed between the left and right renal volume and between male and female (p = 0.12 and 0.68, respectively). For fetuses GA ≥ 30 weeks the right kidney was slightly larger than the left side (n = 100, p = 0.039).
The present study provides reference data for normal fetal renal volumes, which may enable to identify fetuses at risk to develop congenital oligonephropathy.
本研究旨在通过磁共振（MR）容积测量为正常胎儿肾脏生长提供参考值，并探讨其侧别和性别差异。
回顾分析 2003 年 1 月至 2009 年 12 月期间在我院行单胎妊娠胎儿 MR 检查的病例，排除肾盂输尿管畸形、宫内生长受限、多发畸形、羊水过少或过多、母亲糖尿病等影响胎儿肾脏体积测量的病例。在解剖图像上，通过勾画所有层面的肾脏轮廓并将其组合成一个肾脏体积来进行肾脏体积测量。采用多项式回归分析来评估肾脏体积随胎龄（GA）的变化。
对 240 例 GA 为 20 至 37 周的胎儿的 274 次 MR 检查双侧肾脏体积进行了计算。肾脏体积与 GA 呈强相关性（多项式回归分析，p < 0.001）。左、右肾体积和男、女之间无明显差异（p = 0.12 和 0.68）。对于 GA ≥ 30 周的胎儿，右侧肾脏略大于左侧（n = 100，p = 0.039）。
本研究提供了正常胎儿肾脏体积的参考值，有助于识别可能患有先天性肾发育不良的胎儿。
