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[小儿肝移植。手术方面]

[The pediatric liver transplant. The surgical aspects].

作者信息

Vázquez J, Gámez M, Turrión V, Murcia J, Santamaría M L, Díaz M C, Ardaiz J, Camarena C, de la Vega A, de Vicente E

机构信息

Unidad Interhospitalaria, Hospital Infantil La Paz, Madrid.

出版信息

Cir Pediatr. 1990 Jan;3(1):8-12.

PMID:2073472
Abstract

The Liver Transplant Program was begun at "La Paz" Children's Hospital on January 1986 after a long period of experimental activities. This was the first experience in the Madrid Community. From January 1986 to June 1989 we made 32 orthotopic liver transplants in 25 patients, seven received a second graft and one them received a liver segment because the donor had a large liver. 114 patients were evaluated but only 84 were considered candidates for liver transplantation. The different diseases of the transplants were: biliary atresia (9), Alagille syndrome (4), deficit alpha 1-antitrypsin (3), autoimmune hepatitis (2), neonatal hepatitis (1), Byler disease (1), Wolman disease (1). absent bile ducts (1), Wilson disease (1). Surgical technique was the same that has been described by Starzl using Eurocollins and lactate Ringer. In the 100% we made multiorgan procurement, liver and kidneys, 7% with heart and two heart-lung with hypothermia. In one occasion the donor operation was done out of the country (RFA--Düsseldorf). We never used by-pass during anhepatic phase. Arterial reconstruction was done by end-to-end anastomosis and in five patients we used aortic graft. Our arterial thrombosis rate was 18%. In one patient the portal vein was atrophic and we used a femoral graft between superior mesenteric vein and donor portal vein. For biliary reconstruction we used Roux-en-Y with intraluminal stent in 18 cases and choledocho-choledochus anastomosis in seven cases. Four patients had biliary complications: two biliary fistulas secondary to arterial thrombosis, biliary stenosis and bowel perforation by the intraluminal stent.(ABSTRACT TRUNCATED AT 250 WORDS)

摘要

1986年1月,经过长期的实验活动后,“拉巴斯”儿童医院启动了肝移植项目。这是马德里自治区的首例此类尝试。从1986年1月至1989年6月,我们对25名患者进行了32例原位肝移植,其中7人接受了第二次移植,1人接受了肝段移植,因为供体肝脏较大。共评估了114名患者,但只有84名被认为是肝移植候选者。移植所针对的不同疾病包括:胆道闭锁(9例)、阿拉吉尔综合征(4例)、α1抗胰蛋白酶缺乏症(3例)、自身免疫性肝炎(2例)、新生儿肝炎(1例)、比勒病(1例)、沃尔曼病(1例)、胆管缺如(1例)、威尔逊病(1例)。手术技术与斯塔兹所描述的相同,使用欧罗克林液和乳酸林格液。我们100%进行了多器官获取,即肝脏和肾脏,7%获取了心脏,2例获取了心肺,并采用了低温技术。有一次供体手术在国外进行(德国杜塞尔多夫的RFA)。无肝期我们从未使用体外循环。动脉重建采用端端吻合,5例患者使用了主动脉移植物。我们的动脉血栓形成率为18%。1例患者门静脉萎缩,我们在肠系膜上静脉和供体门静脉之间使用了股静脉移植物。胆道重建方面,18例采用了带腔内支架的Roux-en-Y吻合术,7例采用了胆总管-胆总管吻合术。4例患者出现了胆道并发症:2例因动脉血栓形成继发胆瘘,1例胆道狭窄,1例因腔内支架导致肠穿孔。(摘要截选至250字)

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