Solov'eva N A, Lysenko A I
Arkh Patol. 2010 May-Jun;72(3):19-23.
The cytological technique was used to study autopsy specimens from 39 patients aged 35-85 years. Above the atherosclerotic strips and plaques there were multiple destruction microfoci (MDMs) of endothelial cells (EC), which were divided into three types. EC MDMs were detected in the aortic intima in 79.5% of the patients. A total of 107 MDM of different types were found in 63.2% of cases. A total of 53 MDMs were identified. The detection rate for EC MDMs in the aorta and coronary arteries in acute and recurrent myocardial infarction was 1.3 and 2 times greater than that in large-focal and diffuse small-focal cardiosclerosis. EC microfocal destruction is a sign of progressive atherosclerosis and may be a critical step in the transition from stable endothelized to eroded plaque and thrombosis.
采用细胞学技术研究了39例年龄在35 - 85岁患者的尸检标本。在动脉粥样硬化条纹和斑块上方存在内皮细胞（EC）的多个破坏微灶（MDM），其分为三种类型。79.5%的患者在主动脉内膜中检测到EC MDM。63.2%的病例中总共发现了107个不同类型的MDM。总共鉴定出53个MDM。急性和复发性心肌梗死患者主动脉和冠状动脉中EC MDM的检出率分别比大灶性和弥漫性小灶性心肌病高出1.3倍和2倍。EC微灶性破坏是动脉粥样硬化进展的标志，可能是从稳定的内皮化斑块转变为糜烂斑块和血栓形成的关键步骤。
