Alieva T U, Fedorov S V, Sviridov S V
Anesteziol Reanimatol. 2010 May-Jun(3):8-12.
The paper considers postoperative imbalance of the trace elements zinc and copper in 40 surgical patients aged 47.2 +/- 17.1 years who have extensive purulent soft tissue wounds (PSTW). In 90% of the patients with PSTW, plasma Zn++ levels were much lower than the reference values (the normal value was 11.1-19.5 micromol/l) while in 47.5%, serum Zn++ was in the range of less than 7 micromol/l, which is a poor prognostic factor. There was a negative correlation between the level of Zn++ and that of C-reactive protein (CRP) and a positive correlation between the former and the magnitude of a reduction in transferrin (TF) as a marker of protein-energy malnutrition. Plasma Cu/Zn ratio is shown to be of very clinical importance. The higher this ratio (normal ratio 0.9-1.13) is, the more severe the general condition of patients with PSTW, the higher CRP values (above 120 mg/l; normal value 0-6 mg/l), and the lower TF levels are. In patients with PSTW, zinc level and Cu/Zn ratio may act as an independent predictor of a grave condition during a systemic inflammatory reaction.
该论文研究了40名年龄在47.2±17.1岁、患有广泛化脓性软组织伤口（PSTW）的外科手术患者术后微量元素锌和铜的失衡情况。在90%的PSTW患者中，血浆锌离子（Zn++）水平远低于参考值（正常值为11.1 - 19.5微摩尔/升），而在47.5%的患者中，血清锌离子低于7微摩尔/升，这是一个不良预后因素。锌离子水平与C反应蛋白（CRP）水平呈负相关，与作为蛋白质 - 能量营养不良标志物的转铁蛋白（TF）降低幅度呈正相关。血浆铜/锌比值显示出非常重要的临床意义。该比值越高（正常比值为0.9 - 1.13），PSTW患者的一般状况越严重，CRP值越高（高于120毫克/升；正常值为0 - 6毫克/升），TF水平越低。在PSTW患者中，锌水平和铜/锌比值可能是全身炎症反应期间病情严重程度的独立预测指标。
