Department of Internal Medicine, Hôtel Dieu, Hospices Civils de Lyon, and University Claude Bernard Lyon 1, Lyon, France.
Ocul Immunol Inflamm. 2011 Feb;19(1):26-31. doi: 10.3109/09273948.2010.505357. Epub 2010 Aug 25.
To assess the value of lumbar punctures in adult patients with unexplained intermediate uveitis (IU).
Retrospective study of 17 patients with unexplained IU. All the patients underwent physical examination, complete laboratory tests, and cerebrospinal MRI.
Out of the 12 patients who underwent a lumbar puncture, six had oligoclonal bands and/or increased IgG index.
Intrathecal synthesis of immunoglobulins is not rare in patients with unexplained IU. A longer follow-up is mandatory to determine whether intrathecal immunoglobulins synthesis has a predictive value for subsequent progression to multiple sclerosis.
评估腰椎穿刺术在成人不明原因中间葡萄膜炎（IU）患者中的价值。
回顾性研究 17 例不明原因 IU 患者。所有患者均行体格检查、全实验室检查和脑脊髓 MRI。
在 12 例行腰椎穿刺术的患者中，6 例出现寡克隆带和/或 IgG 指数升高。
不明原因 IU 患者的鞘内免疫球蛋白合成并不罕见。需要进行更长时间的随访，以确定鞘内免疫球蛋白合成是否对随后进展为多发性硬化具有预测价值。
