Loyola University Medical Center, Maywood, IL 60153, USA.
Expert Rev Anticancer Ther. 2010 Aug;10(8):1273-83. doi: 10.1586/era.10.106.
In women with advanced breast cancer or those with early-stage cancer for whom there is a contraindication for breast-conserving therapy, mastectomy is the primary surgical treatment. This is often followed by breast reconstruction in either an immediate or delayed fashion. There is a great psychological and emotional benefit for the patient to have immediate reconstruction at the time of initial mastectomy. Recently, evidence has demonstrated that postmastectomy radiation therapy (PMRT) administered in conjunction with systemic therapy improves not only locoregional control but also survival. This has increased the number of women receiving PMRT and resulted in much debate in the literature regarding the timing of radiation therapy and the types of reconstructive options. In this article, the authors review the literature for controversies and currently accepted practices for intermeshing PMRT and breast reconstruction following mastectomy. We also summarize the key issues related to the integration of breast reconstruction with PMRT and detail the experience and complications arising from this integration.
对于患有晚期乳腺癌或不适合保乳治疗的早期乳腺癌患者，乳房切除术是主要的手术治疗方法。通常在乳房切除术后立即或延迟进行乳房重建。对于患者来说，在初次乳房切除时立即进行重建具有极大的心理和情感益处。最近，有证据表明，乳房切除术加放疗（PMRT）联合全身治疗不仅可以改善局部区域控制，还可以改善生存。这增加了接受 PMRT 的女性数量，并在文献中引发了关于放疗时间和重建选择类型的大量争论。本文作者回顾了有关 PMRT 和乳房切除术后乳房重建相结合的争议和当前接受的实践的文献。我们还总结了与 PMRT 与保乳术相结合相关的关键问题，并详细介绍了从这种结合中产生的经验和并发症。
