Cook Greg W, LaPuma Peter T, Hook Gary L, Eckenrode Brian A
Department of Preventive Medicine and Biometrics, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Road, Bethesda, MD 20814, USA.
J Forensic Sci. 2010 Nov;55(6):1582-91. doi: 10.1111/j.1556-4029.2010.01522.x.
Ion mobility spectrometry (IMS) is a valued field detection technology because of its speed and high sensitivity, but IMS cannot easily resolve analytes of interest within mixtures. Coupling gas chromatography (GC) to IMS adds a separation capability to resolve complex matrices. A GC-IONSCAN® operated in IMS and GC⁄ IMS modes was evaluated with combinations of five explosives and four interferents. In 100 explosive/interferent combinations, IMS yielded 21 false positives while GC⁄ IMS substantially reduced the occurrence of false positives to one. In addition, the results indicate that through redesign or modification of the preconcentrator there would be significant advantages to using GC⁄ IMS, such as enhancement of the linear dynamic range (LDR) in some situations. By balancing sensitivity with LDR, GC⁄ IMS could prove to be a very advantageous tool when addressing real world complex mixture situations.
离子迁移谱（IMS）因其速度快和灵敏度高而成为一种有价值的现场检测技术，但IMS难以轻易分辨混合物中感兴趣的分析物。将气相色谱（GC）与IMS联用增加了分离复杂基质的能力。对一台以IMS和GC/IMS模式运行的GC-IONSCAN® 进行了评估，评估对象为五种炸药和四种干扰物的组合。在100种炸药/干扰物组合中，IMS产生了21例假阳性结果，而GC/IMS将假阳性结果的发生率大幅降低至一例。此外，结果表明，通过对预浓缩器进行重新设计或改进，使用GC/IMS将具有显著优势，比如在某些情况下可扩大线性动态范围（LDR）。通过平衡灵敏度和LDR，在处理实际复杂混合物情况时，GC/IMS可能被证明是一种非常有利的工具。
