[视网膜环核苷酸磷酸二酯酶的蛋白质抑制剂：其在光感受器外段的定位]
[Protein inhibitor of the retinal cyclic nucleotide phosphodiesterase: its localization in the outer segment of a photoreceptor].
作者信息
Berman A L, Usova A A
出版信息
Biokhimiia. 1978 Mar;43(3):486-90.
The content of a protein inhibitor of the cyclic nucleotides phosphodiesterase (PDE) in different retinal preparations as well as its distribution in the subfractions of rod outer segments (ROS) was studied. The content of protein inhibitor of PDE in different preparations of the retina was found to correlate with the rhodopsin content. The distribution of this protein over different ROS subfractions appeared to be exactly the same as that of rhodopsin, the content of protein inhibitor of PDE being more than a half of its content in the native ROS. The protein inhibitor of PDE could be easily washed out from the ROS fractions. It is concluded that the cattle protein inhibitor of PDE is localized in ROS, and is absent in the other retinal layers.
研究了不同视网膜制剂中环核苷酸磷酸二酯酶（PDE）蛋白抑制剂的含量及其在视杆外段（ROS）亚组分中的分布。发现视网膜不同制剂中PDE蛋白抑制剂的含量与视紫红质含量相关。该蛋白在不同ROS亚组分中的分布似乎与视紫红质完全相同，PDE蛋白抑制剂的含量超过其在天然ROS中含量的一半。PDE蛋白抑制剂很容易从ROS组分中洗出。得出的结论是，牛PDE蛋白抑制剂定位于ROS中，而在视网膜的其他层中不存在。
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