Department of Epidemiology and Preventive Medicine, University of Maryland Baltimore, Baltimore, MD 21201, USA.
Emerg Infect Dis. 2010 Sep;16(9):1419-27. doi: 10.3201/eid1609.091802.
To assess the association of illicit drug use and USA300 methicillin-resistant Staphylococcus aureus (MRSA) bacteremia, a multicenter study was conducted at 4 Veterans Affairs medical centers during 2004-2008. The study showed that users of illicit drugs were more likely to have USA300 MRSA bacteremia (in contrast to bacteremia caused by other S. aureus strains) than were patients who did not use illicit drugs (adjusted relative risk 3.0; 95% confidence interval 1.9-4.4). The association of illicit drug use with USA300 MRSA bacteremia decreased over time (p = 0.23 for trend). Notably, the proportion of patients with USA300 MRSA bacteremia who did not use illicit drugs increased over time. This finding suggests that this strain has spread from users of illicit drugs to other populations.
为了评估非法药物使用与 USA300 型耐甲氧西林金黄色葡萄球菌（MRSA）菌血症之间的关联，在 2004 年至 2008 年期间，在 4 家退伍军人事务部医疗中心进行了一项多中心研究。研究表明，与未使用非法药物的患者相比，非法药物使用者更有可能患有 USA300 型 MRSA 菌血症（调整后的相对风险 3.0；95%置信区间 1.9-4.4）。非法药物使用与 USA300 型 MRSA 菌血症之间的关联随时间的推移而减弱（趋势检验 p = 0.23）。值得注意的是，未使用非法药物的 USA300 型 MRSA 菌血症患者的比例随时间的推移而增加。这一发现表明，这种菌株已经从非法药物使用者传播到其他人群。
