Dipartimento di Genetica e Biologia Molecolare, Università di Roma La Sapienza, P.le Aldo Moro 5, 00185, Roma, Italy.
Neurobiol Learn Mem. 2010 Oct;94(3):373-81. doi: 10.1016/j.nlm.2010.08.004. Epub 2010 Aug 22.
In this study the immediate-early gene Fos was used to investigate the response to different novel stimuli in a wide array of brain regions including the hippocampus, the rhinal cortex, the frontal cortex and different components of the striatal complex. Independent groups of CD-1 mice were exposed to three different novelty conditions: (1) novel environment (empty open field); (2) complex novel environment (i.e. open field containing objects); and (3) identity-based detection of novel objects. We observed that a complex novel environment and a knowledge-based novelty modulated Fos levels in both the dorsal and the ventral components of the striatum, while Fos immunoreactivity in the medial temporal lobe was only increased after exposure to novel environments, regardless of their complexity. Finally, we observed a strong increase of Fos levels in the prefrontal cortex in all the three novel conditions examined, indicating a major involvement of this structure in novelty assessment. Overall the present study demonstrates that distinct brain regions are recruited in different kinds of novelty and emphasizes the role of the striatal complex in processing complex novel information.
在这项研究中，使用即刻早期基因 Fos 来研究广泛的脑区（包括海马体、嗅皮层、额叶皮层和纹状体复合体的不同组成部分）对不同新刺激的反应。独立的 CD-1 小鼠组被暴露于三种不同的新颖环境条件下：（1）新环境（空旷的开阔场）；（2）复杂新颖环境（即包含物体的开阔场）；和（3）基于身份的新颖物体检测。我们观察到，复杂新颖环境和基于知识的新颖性调节了纹状体背侧和腹侧成分中的 Fos 水平，而内侧颞叶的 Fos 免疫反应仅在暴露于新颖环境后增加，而不论其复杂性如何。最后，我们观察到在所有三种被检查的新颖条件下，前额叶皮层的 Fos 水平都有强烈增加，表明该结构在新颖性评估中起主要作用。总体而言，本研究表明不同的脑区被招募到不同类型的新颖性中，并强调了纹状体复合体在处理复杂新颖信息中的作用。
