Department of Medicine and Therapeutics, Chelsea and Westminster Hospital, London SW10 9NH, UK.
QJM. 2010 Dec;103(12):959-63. doi: 10.1093/qjmed/hcq146. Epub 2010 Aug 23.
Cardiac computed tomography (CCT) is a well-validated investigation for the non-invasive assessment of coronary artery disease (CAD). The National Institute for Clinical Excellence (NICE) have recently released guidelines incorporating CCT into the diagnostic algorithm for chest pain of recent onset.
To assess the frequency of eligibility for CCT in medical admissions with suspected cardiac chest pain using criteria defined by NICE.
A retrospective, observational study, set in a teaching hospital acute medical unit.
A total of 198 consecutive patients admitted over a 4-month period with suspected cardiac chest pain (57% male; mean age 63.5 years) were assessed for eligibility for CCT based on NICE guideline criteria.
Of the 198 patients admitted, 65 (33%) patients were excluded by a raised troponin I or ischaemic ECG changes; 100 (51%) patients were excluded by pain categorized as non-anginal and 171 (86%) patients were excluded by a modified Diamond Forrester score outside the range 10-29%. Applying NICE criteria to this population ultimately resulted in 2 (1%) patients recommended for CCT, 12 (6%) for functional cardiac testing and 17 (9%) for invasive angiography.
Applying current NICE guidelines for chest pain of recent onset to medical admissions results in a lesser uptake of CCT than functional testing and invasive angiography. If the NICE guidelines are revised to include patients with an intermediate pre-test probability of CAD, CCT may have a greater role.
心脏计算机断层扫描(CCT)是一种经过充分验证的非侵入性冠状动脉疾病(CAD)评估方法。英国国家卫生与临床优化研究所(NICE)最近发布了指南,将 CCT 纳入近期新发胸痛的诊断算法中。
根据 NICE 定义的标准,评估疑似心脏性胸痛的医疗入院患者进行 CCT 的适宜性频率。
一项回顾性、观察性研究,在教学医院急症内科进行。
在 4 个月的时间里,对连续 198 例因疑似心脏性胸痛而入院的患者进行 CCT 适宜性评估,这些患者符合 NICE 指南标准。
在 198 例入院患者中,有 65 例(33%)因肌钙蛋白 I 升高或缺血性心电图改变而被排除在外;100 例(51%)因疼痛被归类为非心绞痛而被排除在外;171 例(86%)因改良 Diamond Forrester 评分不在 10-29%范围内而被排除在外。按照 NICE 标准对该人群进行评估,最终只有 2 例(1%)患者推荐进行 CCT,12 例(6%)患者进行心脏功能测试,17 例(9%)患者进行有创血管造影。
将近期新发胸痛的 NICE 指南应用于医疗入院患者,导致 CCT 的应用率低于心脏功能测试和有创血管造影。如果 NICE 指南修订纳入 CAD 预测概率处于中间水平的患者,CCT 的应用可能会更大。