达芦那韦在感染 HIV-1 的男性精液中的浓度超过了野生型 HIV 的蛋白校正 EC₅₀。

Darunavir concentrations exceed the protein-corrected EC₅₀ for wild-type HIV in the semen of HIV-1-infected men.

机构信息

Department of Sexual Health and HIV Medicine, Directorate of Infection, Birmingham Heartlands Hospital, Birmingham, UK.

出版信息

AIDS. 2010 Oct 23;24(16):2583-7. doi: 10.1097/QAD.0b013e32833ead18.

PMID:20736813

Abstract

Variable antiretroviral drug penetration into the genital tract may contribute to the differential evolution of HIV-1 and the emergence of drug resistance. We compared concentrations of darunavir in 34 time-matched blood plasma and seminal plasma samples from 18 HIV-1 positive men. Darunavir in seminal plasma were approximately 10-20% of that achieved in blood at matched time points postdrug ingestion. All seminal plasma darunavir were above the protein-corrected EC₅₀ values for wild-type HIV-1.

摘要

可变的抗逆转录病毒药物渗透到生殖道可能有助于 HIV-1 的差异进化和耐药性的出现。我们比较了 18 例 HIV-1 阳性男性的 34 对时间匹配的血血浆和精浆样本中的达芦那韦浓度。在药物摄入后匹配的时间点，精浆中的达芦那韦大约是血药浓度的 10-20%。所有精浆中的达芦那韦均高于野生型 HIV-1 的蛋白校正 EC₅₀ 值。