Physiopathological and physicochemical considerations in targeting of colloids and drug carriers to the bone marrow.

The ability of the bone marrow to remove particulate matters from the circulation, opens up perhaps an opportunity for the delivery of therapeutic agents by means of colloidal drug carrier systems such as liposomes, emulsions, nanoparticles, etc. for the treatment of diseases and disorders of this multifunctional organ of the body. This article is designed to provide a critical review on fundamentals, problems, current progress, and future prospects of site-specific delivery of intravenously injected colloidal drug carriers to the bone marrow.