Bagwe R P, Kanicky J R, Palla B J, Patanjali P K, Shah D O
Center for Surface Science and Engineering, Dept. of Chemical Engineering, University of Florida, Gainesville, FL 32611, USA.
Crit Rev Ther Drug Carrier Syst. 2001;18(1):77-140.
Microemulsions are excellent candidates as potential drug delivery systems because of their improved drug solubilization, long shelf life, and ease of preparation and administration. The formulation of microemulsions for pharmaceutical use requires a thorough understanding of the properties, uses, and limitations of microemulsions. Three distinct microemulsions--oil external, water external, and middle phase--can be used for drug delivery, depending upon the type of drug and the site of action. In this article, we present an examination of microemulsions as drug carrier systems, starting with general information and moving to a thorough review of the microemulsion literature, with a special section devoted to microemulsion-based gels.
微乳剂因其能改善药物溶解性、保质期长、易于制备和给药，是作为潜在药物递送系统的理想选择。用于制药的微乳剂配方需要全面了解微乳剂的性质、用途和局限性。根据药物类型和作用部位，三种不同的微乳剂——油包型、水包型和中间相型——可用于药物递送。在本文中，我们将对作为药物载体系统的微乳剂进行研究，首先介绍一般信息，然后全面回顾微乳剂文献，并设有专门章节介绍基于微乳剂的凝胶。
