Vargová Viola, Pytliak Marek, Mechírová Viola, Felšöci Marek
Pavol Jozef Šafárik University, Košice, Slovak Republic.
Wien Med Wochenschr. 2010 Sep;160(17-18):470-4. doi: 10.1007/s10354-010-0824-z. Epub 2010 Aug 24.
Aim of this study was to compare the thyroidal status of mothers to children with and without congenital malformations (CM).
We examined 129 mothers of newborns with CM and 228 mothers without CM. The assessment included particular history, physical examination, thyroid ultrasonography, fT4, TSH, and anti-TPO measurement of mothers and comparison to birth proportions of newborns.
The total volume of the thyroid gland and anti-TPO levels were significantly higher in mothers of the group with CM (p < 0.001 and p < 0.01, respectively). The birth weight and length were significantly lower in the group with congenital malformation when compared to controls (p < 0.0001 and p < 0.001, respectively).
Based on the results of our study, we suggest that thyroid diseases of a mother might participate in congenital malformations of their newborn, although no direct association between thyroid autoantibodies and congenital malformations has been described as of yet.
