增加并支持感染艾滋病毒/艾滋病的有色人种人士参与艾滋病临床试验。
Increasing and supporting the participation of persons of color living with HIV/AIDS in AIDS clinical trials.
机构信息
New York University College of Nursing, 726 Broadway, New York, NY 10003, USA.
出版信息
Curr HIV/AIDS Rep. 2010 Nov;7(4):194-200. doi: 10.1007/s11904-010-0055-3.
Abstract
Persons living with HIV/AIDS (PLHA) of color are under-represented in AIDS clinical trials (ACTs), which may limit the generalizability of research findings and denies many individuals access to high levels of care and new treatments available through ACTs. Disproportionately low rates of recruitment in health care settings and by providers are a major barrier to ACTs for this group. Moreover, PLHA of color are more likely than their white peers to decline to participate, mainly due to fear and mistrust (although willingness is also high), negative social norms about ACTs, and difficulty navigating the unfamiliar ACT system. We describe a small number of successful behavioral and structural interventions to increase the participation of PLHA of color in screening for and enrollment into ACTs. HIV care settings, clinical trials sites, and trial sponsors are uniquely positioned to develop procedures, supports, and trials to increase the proportion of PLHA of color in ACTs.
摘要
有色人种的艾滋病毒/艾滋病患者（PLHA）在艾滋病临床研究（ACTs）中的代表性不足，这可能限制了研究结果的普遍性，并使许多人无法获得通过 ACTs 提供的高水平护理和新治疗方法。在医疗保健环境中以及由提供者进行的招募比例不成比例地低，这是该群体参与 ACT 的主要障碍。此外，有色人种的 PLHA 比他们的白人同龄人更有可能拒绝参与，主要是因为恐惧和不信任（尽管意愿也很高）、对 ACT 的负面社会规范以及难以驾驭陌生的 ACT 系统。我们描述了一些成功的行为和结构干预措施，以增加有色人种 PLHA 参与 ACT 筛查和注册的比例。艾滋病毒护理环境、临床试验场所和试验赞助商具有独特的地位，可以制定程序、提供支持和开展试验，以增加 ACT 中有色人种 PLHA 的比例。
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