Straffen A M, Carmichael D J, Fairney A, Hulme B, Snell M E
Department of Chemical Pathology, St. Mary's Hospital and Medical School, Paddington, London, UK.
Clin Chim Acta. 1990 Dec 13;193(1-2):55-63. doi: 10.1016/0009-8981(90)90007-f.
A study has been undertaken to document in detail some of the changes that occur following parathyroidectomy in chronic renal failure patients. In an attempt to predict more precisely the timing of the post-operative hypocalcaemia, serum parathyroid hormone (PTH) concentrations were measured in six patients with renal osteodystrophy undergoing subtotal parathyroidectomy [5] and total parathyroidectomy [1]. The values obtained were related to post-operative changes in serum calcium and albumin concentrations. The intact-PTH concentration in serum was shown to decline rapidly post-operatively while the C-terminal PTH followed a more gradual course. Neither total nor ionised serum calcium concentrations exhibited a correspondingly dramatic fall after parathyroidectomy and the serum albumin concentration remained unaltered.
一项研究旨在详细记录慢性肾衰竭患者甲状旁腺切除术后发生的一些变化。为了更精确地预测术后低钙血症的发生时间，对6例接受甲状旁腺次全切除术[5]和甲状旁腺全切除术[1]的肾性骨营养不良患者测定了血清甲状旁腺激素（PTH）浓度。所获得的值与术后血清钙和白蛋白浓度的变化相关。血清中完整PTH浓度术后迅速下降，而C末端PTH下降过程较为缓慢。甲状旁腺切除术后，血清总钙和离子钙浓度均未出现相应的显著下降，血清白蛋白浓度保持不变。
