General Surgery Unit, Misericordia and Dolce Hospital, Prato, Italy.
Head Neck. 2011 Jun;33(6):840-6. doi: 10.1002/hed.21543. Epub 2010 Aug 24.
The objective of this 2-arm, double-blind, randomized, controlled study was to assess the effects of a preoperative single dose steroid on postoperative nausea and vomiting (PONV), pain, and vocal function after thyroidectomy for benign disease.
We randomized 102 patients into 2 groups from January to December 2009: (1) treatment with 8 mg/2 mL of dexamethasone and (2) treatment with 2 mL NaCl 0.9%, both administered intravenously before anesthesia.
The severity of nausea and the need for antiemetic drugs were reduced in patients receiving dexamethasone (p = .0001). Dexamethasone patients reported significantly less pain (p = .008); the need for analgesic drugs was lower in the dexamethasone group (p = .048). No differences were noted with regard to subjective voice analysis (p = .693).
Dexamethasone (8 mg IV) is a safe and effective method to reduce PONV and pain after thyroid resection and should be used routinely.
本研究为 2 组、双盲、随机、对照研究，旨在评估术前单次使用皮质类固醇对良性疾病甲状腺切除术患者术后恶心呕吐（PONV）、疼痛和嗓音功能的影响。
2009 年 1 月至 12 月，我们将 102 例患者随机分为两组：（1）治疗组接受 8mg/2mL 地塞米松静脉注射，（2）对照组接受 2mL 生理盐水静脉注射，均在麻醉前给药。
接受地塞米松治疗的患者恶心严重程度和需要使用止吐药物的情况减少（p=0.0001）。地塞米松组患者疼痛明显减轻（p=0.008），需要使用镇痛药的患者减少（p=0.048）。主观嗓音分析未见差异（p=0.693）。
地塞米松（8mg 静脉注射）是一种安全有效的方法，可减少甲状腺切除术后 PONV 和疼痛，应常规使用。
