高剂量静脉注射甲氨蝶呤治疗鼻咽癌脑膜转移患者的长期生存。
Long-term survival of a patient with leptomeningeal involvement by nasopharyngeal carcinoma after treatment with high-dose intravenous methotrexate.
机构信息
Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
出版信息
Head Neck. 2012 Feb;34(2):296-300. doi: 10.1002/hed.21516. Epub 2010 Aug 24.
Abstract
BACKGROUND
Nasopharyngeal carcinoma with leptomeningeal involvement is rare and typically has poor prognosis.
METHODS AND RESULTS
We present a case report of a patient with nasopharyngeal carcinoma who was treated with high-dose intravenous methotrexate and remains asymptomatic and without clinical evidence of disease 6 years later.
CONCLUSIONS
Systemic high-dose methotrexate should be evaluated in the treatment of advanced nasopharyngeal carcinoma with central nervous involvement.
摘要
背景
鼻咽癌合并脑膜转移较为罕见，且通常预后较差。
方法和结果
我们报告了一例接受大剂量静脉注射甲氨蝶呤治疗的鼻咽癌患者，6 年后患者无症状，且无疾病临床证据。
结论
全身大剂量甲氨蝶呤治疗应在伴有中枢神经系统侵犯的晚期鼻咽癌治疗中进行评估。
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