Breast and Endocrine Surgical Unit, Oslo University Hospital, Oslo, Norway.
Psychooncology. 2011 Oct;20(10):1102-7. doi: 10.1002/pon.1822. Epub 2010 Aug 25.
The purpose was to investigate whether self-reported health-related quality-of-life (HRQOL) parameters at time of diagnosis and/or 1-year follow-up are prognostic for disease-free survival (DFS) in early-stage breast cancer patients.
Data from 195 women, diagnosed with early-stage breast cancer, who had filled in the EORTC QLQ-C30 and the Hospital Anxiety and Depression Scale (HADS) at time of diagnosis and 1 year after surgery, were analyzed.
After a median follow-up of 8.2 years (range 0.09-9.45), 27 (14.1%) deaths and 22 (11.5%) recurrences were observed. Using Cox multivariate regression analysis, appetite loss reported 1-year following surgery (HR 2.92, 95% CI 1.50-5.66), p=0.002) was significantly predictive for shorter DFS, even after controlling for age and depression. None of the clinical or biological prognostic factors was found to have a confounding effect.
The findings indicate that loss of appetite probably is of prognostic value in addition to well-recognized clinical and biological data, in early-stage breast cancer.
研究在诊断时和/或 1 年随访时自我报告的健康相关生活质量（HRQOL）参数是否与早期乳腺癌患者的无病生存（DFS）相关。
分析了 195 名诊断为早期乳腺癌且在诊断时和手术后 1 年填写 EORTC QLQ-C30 和医院焦虑抑郁量表（HADS）的女性的数据。
中位随访 8.2 年（范围 0.09-9.45）后，观察到 27 例（14.1%）死亡和 22 例（11.5%）复发。使用 Cox 多变量回归分析，术后 1 年报告的食欲丧失（HR 2.92，95%CI 1.50-5.66）与较短的 DFS 显著相关，即使在控制年龄和抑郁后也是如此。未发现任何临床或生物学预后因素存在混杂影响。
这些发现表明，食欲丧失可能除了公认的临床和生物学数据外，在早期乳腺癌中也具有预后价值。
