Ivlieva N Iu
Zh Vyssh Nerv Deiat Im I P Pavlova. 2010 May-Jun;60(3):259-78.
A review. The midbrain dopaminergic system is traditionally considered as a 'common neural currency' for rewards of most kinds. There are several competing hypotheses of its precise contribution in behavior: 1) dopamine mediates the pleasure of rewards; 2) dopamine signals a reward prediction error and, thus, is involved in associative learning; 3) dopamine motivates the pursuit of rewards. However, some investigations have questioned the role of the midbrain dopamine in all these processes. Considerable evidence has illustrated that dopamine system is crucially involved in learning and prediction processes, in estimation of the results of activity, in novel stimulus salience attributions, in decision-making processes and, the most important, in estimation of uncertainty. Such mysterious modulation provides our spontaneity and protects against high reactivity.
综述。中脑多巴胺能系统传统上被认为是大多数类型奖励的“通用神经货币”。关于其在行为中的确切作用有几种相互竞争的假说：1）多巴胺介导奖励的愉悦感；2）多巴胺发出奖励预测误差信号，因此参与联想学习；3）多巴胺激发对奖励的追求。然而，一些研究对中脑多巴胺在所有这些过程中的作用提出了质疑。大量证据表明，多巴胺系统在学习和预测过程、活动结果估计、新刺激显著性归因、决策过程以及最重要的不确定性估计中起着至关重要的作用。这种神秘的调节赋予我们自发性，并防止过度反应。
