State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, 201203, People's Republic of China.
J Org Chem. 2010 Sep 17;75(18):6304-7. doi: 10.1021/jo1013614.
A base-promoted one-pot tandem reaction has been developed from 3-(1-alkynyl)chromones with various acetonitriles to afford functionalized amino-substituted xanthones 3 under microwave irradiation. This tandem process involves multiple reactions, such as Michael addition/cyclization/1,2-addition, without a transition metal catalyst. This method provides an efficient approach to build up natural product-like diversified amino-substituted xanthone scaffolds rapidly.
在微波辐射下，3-(1-炔基)色酮与各种乙腈通过基底促进的一锅串联反应得到官能化的氨基取代的呫吨酮 3。该串联过程涉及多种反应，如迈克尔加成/环化/1,2-加成，无需过渡金属催化剂。该方法为快速构建天然产物样的多样化氨基取代呫吨酮骨架提供了一种有效的途径。
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