Department of Pharmacognosy, College of Pharmacy, Sungkyunkwan University, Suwon, South Korea.
Immunopharmacol Immunotoxicol. 2011 Jun;33(2):338-41. doi: 10.3109/08923973.2010.511233. Epub 2010 Aug 25.
The whole plants of Carpesium rosulatum were chloroform extracted and the isolated sesquiterpene lactones and immunotoxicity effects were studied. The structures and stereochemistry of these compounds were established on the basis of analysis of spectra including mp, α(25), IR, UV, EI-MS, MS, (1)H-NMR, (13)C-NMR and some chemical transformations as follows: 1 (4β,10α-dihydroxy-guaia-8α,12-olide), 2 (4β,10α-dihydroxy-1(2),11 (13)-guaiadien -8α,12-olide), 3 (3β,8β-dihydroxy-1α,5α-guaian-10(14)-ene-6α,12-olide). 4 (2β,5-epoxy-5,10-dihydroxy-6α,9β-diangeloyloxy-germacran-8α,12-olide) The chloroform extracted had a significant toxic effect against early fourth-stage larvae of Aedes aegypti L with an LC(50) value of 13.11 ppm and an LC(90) value of 20.33 ppm. The results could be useful in search for newer, safer, and more effective natural immunotoxicity agents against A. aegypti.
用氯仿从苍耳全草中提取分离得到倍半萜内酯，研究了其结构和免疫毒性。根据包括熔点、α(25)、IR、UV、EI-MS、MS、(1)H-NMR、(13)C-NMR 和一些化学转化在内的光谱分析，确定了这些化合物的结构和立体化学，如下所示：1（4β,10α-二羟基-愈创木-8α,12-内酯）、2（4β,10α-二羟基-1(2),11（13）-愈创木-8α,12-内酯）、3（3β,8β-二羟基-1α,5α-愈创木-10(14)-烯-6α,12-内酯）和 4（2β,5-环氧-5,10-二羟基-6α,9β-当归酰氧基-大根香叶-8α,12-内酯）。氯仿提取物对埃及伊蚊四龄早期幼虫具有显著的毒性作用，LC(50)值为 13.11 ppm，LC(90)值为 20.33 ppm。这些结果可能有助于寻找新型、安全、有效的天然免疫毒性剂来对抗埃及伊蚊。
