Neurosciences Centre of Excellence for Drug Discovery, GlaxoSmithKline, New Frontiers Science Park, Harlow, Essex, UK.
Curr Med Chem. 2010;17(30):3503-13. doi: 10.2174/092986710792927840.
This article highlights recent advances in the discovery of new positive allosteric modulators of the AMPA receptor, excluding compounds of thiadiazine chemotype, most of which were developed by Servier and the University of Liège. The field of AMPA receptor modulators continues to be a fertile area for the discovery of new potential therapeutic agents, and recent years have seen a marked diversification in the range of chemotypes prepared. An overview is also given of the recent key new biological data.
本文重点介绍了除噻二嗪类化合物以外，由塞利尔（Servier）和列日大学（University of Liège）开发的新型 AMPA 受体正变构调节剂的最新发现进展。AMPA 受体调节剂领域仍然是发现新的潜在治疗剂的肥沃领域，近年来，所制备的化学型范围明显多样化。本文还概述了最近的关键新生物学数据。
