Department of Dermatology, Great Western Hospital NHS Foundation Trust, Swindon, Wiltshire, UK.
Clin Exp Dermatol. 2011 Apr;36(3):281-3. doi: 10.1111/j.1365-2230.2010.03926.x. Epub 2010 Aug 25.
Subacute cutaneous lupus erythematosus (SCLE) is characterized by annular scaly erythematous plaques in a photosensitive distribution, and the presence of anti-Ro (SSA) and/or anti-La (SSB) antibodies. Most cases of SCLE are idiopathic, but occasional cases may be drug-induced or associated with a hereditary deficiency of complement components. We report two cases of drug-induced SCLE precipitated by the proton pump inhibitor, omeprazole. Drug-induced disease should be considered in all atypical or extensive cases of SCLE, especially in elderly patients.
亚急性皮肤型狼疮（SCLE）的特征是在光敏分布区域出现环状鳞屑性红斑，并且存在抗 Ro（SSA）和/或抗 La（SSB）抗体。大多数 SCLE 是特发性的，但偶尔也可能是药物诱导的，或与补体成分的遗传性缺乏有关。我们报告了两例由质子泵抑制剂奥美拉唑引起的药物诱导的 SCLE 病例。在所有非典型或广泛的 SCLE 病例中，尤其是老年患者，都应考虑药物引起的疾病。
