Hasegawa Satoshi, Sato Seiichi, Numano Fujito, Park Jiksoo, Hoshina Satoshi, Endoh Hikosato, Suzuki Hiroshi, Uchiyama Makoto
Division of Pediatrics, Department of Homeostatic Regulation and Development, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.
Pediatr Int. 2011 Apr;53(2):154-8. doi: 10.1111/j.1442-200X.2010.03235.x.
The second derivative of the photoplethysmogram (SDPTG) has been verified as a useful method for analyzing pulse wave form in adults; however, there have been few studies on the SDPTG in children.
We examined age-related alteration of SDPTG (study 1) and the SDPTG response to a vasodilator (study 2). The subjects in study 1 were 36 healthy children aged 0.9-16.0 years. The subjects in study 2 were 13 children aged 5.4-18.9 years with a history of Kawasaki disease. Subjects received an i.v. infusion of 0.568 mg/kg dipyridamole. We assessed the SDPTG by d/a ratio, b/a ratio and aging index (AGI).
The d/a ratio increased with advance of age (r= 0.636, P < 0.001), and the b/a ratio and AGI decreased with advance of age (r=-0.343, P < 0.05 and r=-0.678, P < 0.001, respectively). The d/a ratio and AGI were correlated with height (r= 0.523, P < 0.01 and r=-0.623, P < 0.001, respectively), but the b/a ratio was not significantly correlated with height. In study 2, the d/a ratio increased significantly (P≤ 0.05), but the b/a ratio and AGI did not alter.
The SDPTG indices in children show characteristic alterations with advance of age and react to a vasodilator.
光电容积脉搏波图的二阶导数（SDPTG）已被证实是分析成人脉搏波形的一种有用方法；然而，关于儿童SDPTG的研究很少。
我们研究了SDPTG与年龄相关的变化（研究1）以及SDPTG对血管扩张剂的反应（研究2）。研究1的受试者为36名年龄在0.9 - 16.0岁的健康儿童。研究2的受试者为13名年龄在5.4 - 18.9岁、有川崎病病史的儿童。受试者接受静脉输注0.568 mg/kg双嘧达莫。我们通过d/a比值、b/a比值和衰老指数（AGI）评估SDPTG。
d/a比值随年龄增长而增加（r = 0.636，P < 0.001），b/a比值和AGI随年龄增长而降低（分别为r = -0.343，P < 0.05和r = -0.678，P < 0.001）。d/a比值和AGI与身高相关（分别为r = 0.523，P < 0.01和r = -0.623，P < 0.001），但b/a比值与身高无显著相关性。在研究2中，d/a比值显著增加（P≤0.05），但b/a比值和AGI没有变化。
儿童的SDPTG指标随年龄增长呈现特征性变化，并对血管扩张剂有反应。
