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[性激素影响下血管壁肌细胞的酶组织化学变化]

[Enzyme histochemical changes in the myocytes of the vascular wall under the influence of sex hormones].

作者信息

Khristova M

出版信息

Eksp Med Morfol. 1990;29(2):52-7.

PMID:2073887
Abstract

Estradiol, progesterone and testosterone were administered three times in the female rats of Wistar strain. Myocytes were studied in the wall of the portal vena, posterior vena cava and aorta. The used histochemical methods showed distribution of dehydrogenases, which was characteristic of predominating anaerobic oxidation in cells. They increased their activity after animals were treated with testosterone and they reduced it after treatment with progesterone. Adenosin-3-phosphatase activity was increased after administration of estradiol and was reduced after treatment with progesterone. Better manifested activity of some enzymes in the longitudinal muscular layer of the portal vena in comparison with circular layer was connected with greater functional loading of this layer. It was found to a great extent similarity in dynamics of enzyme histochemical changes in arterial and venous myocytes.

摘要

对Wistar品系的雌性大鼠三次给予雌二醇、孕酮和睾酮。研究了门静脉壁、后腔静脉和主动脉中的心肌细胞。所采用的组织化学方法显示了脱氢酶的分布,这是细胞中主要进行无氧氧化的特征。用睾酮处理动物后,它们的活性增加,而用孕酮处理后活性降低。给予雌二醇后腺苷-3-磷酸酶活性增加,用孕酮处理后活性降低。与环形肌层相比,门静脉纵行肌层中某些酶的活性表现得更好,这与该层更大的功能负荷有关。发现在动脉和静脉心肌细胞中酶组织化学变化的动态在很大程度上相似。

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