Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin, Israel.
Am J Obstet Gynecol. 2010 Nov;203(5):442.e1-4. doi: 10.1016/j.ajog.2010.06.062. Epub 2010 Aug 24.
We sought to investigate the reproductive outcomes of women who underwent laparoscopic removal of benign cystic teratoma with or without intraoperative spillage.
The reproductive outcomes of reproductive age women following laparoscopic removal of benign cystic teratoma from 1997 through 2007 were investigated by a telephone questionnaire.
In all, 128 reproductive age women underwent benign cystic teratoma removal, and reproductive outcomes were available for 45. Among those 45 women, intraoperative spillage occurred in 16 (35.6%). The rate of spontaneous pregnancies was significantly lower for the nonspillage compared to the intraoperative spillage groups (20/29 [68.9%] vs 16/16 [100%], respectively; P = .01). However, the median time from surgery to the first pregnancy was similar (22 and 18.5 months, respectively; P = .9). From the 9 remaining women in the nonspillage group, 4 conceived with ovulation induction, 2 conceived with in vitro fertilization, and 3 were infertile.
Intraoperative spillage of benign cystic teratomas does not lead to long-term infertility.
研究腹腔镜下切除良性囊性畸胎瘤术中是否发生肿瘤溢漏对女性生殖结局的影响。
通过电话问卷调查,对 1997 年至 2007 年间接受腹腔镜良性囊性畸胎瘤切除术的育龄妇女的生殖结局进行了研究。
共 128 例育龄妇女接受了良性囊性畸胎瘤切除术,其中 45 例有生殖结局数据。在这 45 名妇女中,16 名(35.6%)发生了术中肿瘤溢漏。无肿瘤溢漏组的自发性妊娠率明显高于肿瘤溢漏组(20/29 [68.9%] vs 16/16 [100%];P =.01)。然而,从手术到第一次妊娠的中位时间相似(分别为 22 个月和 18.5 个月;P =.9)。在无肿瘤溢漏组的 9 名剩余妇女中,4 人通过促排卵受孕,2 人通过体外受精受孕,3 人不孕。
良性囊性畸胎瘤术中肿瘤溢漏不会导致长期不孕。