α,ε-二氨基庚二酸、D-α-氨基己二酸和HA-966对蛙和未成熟大鼠离体脊髓中兴奋性氨基酸诱导反应的类镁离子选择性拮抗作用。 - Suppr

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超能文献

Mg2+-like selective antagonism of excitatory amino acid-induced responses by alpha, epsilon-diaminopimelic acid, D-alpha-aminoadipate and HA-966 in isolated spinal cord of frog and immature rat.

作者信息

Evans R H, Francis A A, Watkins J C

出版信息

Brain Res. 1978 Jun 16;148(2):536-42. doi: 10.1016/0006-8993(78)90744-8.

DOI:10.1016/0006-8993(78)90744-8

PMID:207392

Abstract

摘要

相似文献

Mg2+-like selective antagonism of excitatory amino acid-induced responses by alpha, epsilon-diaminopimelic acid, D-alpha-aminoadipate and HA-966 in isolated spinal cord of frog and immature rat.α,ε-二氨基庚二酸、D-α-氨基己二酸和HA-966对蛙和未成熟大鼠离体脊髓中兴奋性氨基酸诱导反应的类镁离子选择性拮抗作用。

Brain Res. 1978 Jun 16;148(2):536-42. doi: 10.1016/0006-8993(78)90744-8.

D-alpha-aminoadipate, alpha, epsilon-diominopimelic acid and HA-966 as antagonists of amino acid-induced and synpatic excitation of mammalian spinal neurones in vivo.D-α-氨基己二酸、α,ε-二氨基庚二酸和HA-966作为体内氨基酸诱导的和哺乳动物脊髓神经元突触兴奋的拮抗剂。

Brain Res. 1978 Jun 16;148(2):543-8. doi: 10.1016/0006-8993(78)90745-x.

Depression of synaptic excitation and of amino acid induced excitatory responses of spinal neurones by D-alpha-aminoadipate, alpha,epsilon-diaminopimelic acid and HA-966.D-α-氨基己二酸、α,ε-二氨基庚二酸和HA-966对脊髓神经元突触兴奋及氨基酸诱导的兴奋性反应的抑制作用。

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Specific antagonism of excitant amino acids in the isolated spinal cord of the neonatal rat.新生大鼠离体脊髓中兴奋性氨基酸的特异性拮抗作用

Eur J Pharmacol. 1978 Jul 15;50(2):123-9. doi: 10.1016/0014-2999(78)90007-9.

Selective antagonism by D-alpha-aminoadipate of amino acid and synaptic excitation of cat spinal neurons.D-α-氨基己二酸对猫脊髓神经元氨基酸及突触兴奋的选择性拮抗作用。

Brain Res. 1978 Sep 8;152(3):603-8. doi: 10.1016/0006-8993(78)91117-4.

D-alpha-Aminoadipate as a selective antagonist of amino acid-induced and synaptic excitation of mammalian spinal neurones.D-α-氨基己二酸作为氨基酸诱导的和哺乳动物脊髓神经元突触兴奋的选择性拮抗剂。

Nature. 1977;270(5639):743-5. doi: 10.1038/270743a0.

The effect of D-alpha-aminoadipate on excitatory amino acid responses recorded intracellularly from motoneurones of the frog spinal cord.

Neurosci Lett. 1984 Aug 24;49(1-2):99-104. doi: 10.1016/0304-3940(84)90143-5.

Depression of ventral root--dorsal root potential by DL-alpha-aminoadipate in frog spinal cord.DL-α-氨基己二酸对蛙脊髓腹根-背根电位的抑制作用

Brain Res. 1981 Mar 9;208(1):240-3. doi: 10.1016/0006-8993(81)90641-7.

Effects of D,L-alpha-aminoadipate on postsynaptic amino acid responses in cultured mouse spinal cord neurons.D，L-α-氨基己二酸对培养的小鼠脊髓神经元突触后氨基酸反应的影响。

Brain Res. 1980 Jul 7;193(1):199-207. doi: 10.1016/0006-8993(80)90957-9.

Specific effects of alpha-D,L-aminoadipic acid on synaptic transmission in frog spinal cord.α-D，L-氨基己二酸对青蛙脊髓突触传递的特定作用。

Can J Physiol Pharmacol. 1980 Jun;58(6):692-8. doi: 10.1139/y80-111.

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The dissociative anaesthetics, ketamine and phencyclidine, selectively reduce excitation of central mammalian neurones by N-methyl-aspartate.分离麻醉药氯胺酮和苯环己哌啶可选择性降低N-甲基天冬氨酸对中枢哺乳动物神经元的兴奋作用。

Br J Pharmacol. 1983 Jun;79(2):565-75. doi: 10.1111/j.1476-5381.1983.tb11031.x.

Selective depression of excitatory amino acid induced depolarizations by magnesium ions in isolated spinal cord preparations.在离体脊髓标本中镁离子对兴奋性氨基酸诱导的去极化的选择性抑制作用

J Physiol. 1980 Oct;307:413-28. doi: 10.1113/jphysiol.1980.sp013443.

The antagonism of amino acid-induced excitations of rat hippocampal CA1 neurones in vitro.体外实验中氨基酸诱导的大鼠海马CA1神经元兴奋的拮抗作用

J Physiol. 1983 Jan;334:19-31. doi: 10.1113/jphysiol.1983.sp014477.

The nature of the excitatory transmitter mediating X and Y cell inputs to the cat dorsal lateral geniculate nucleus.介导猫背外侧膝状核X和Y细胞输入的兴奋性递质的性质。

J Physiol. 1982 Feb;323:377-91. doi: 10.1113/jphysiol.1982.sp014078.

Stimulation of rat cerebellar guanosine 3',5'-cyclic monophosphate (cyclic GMP) levels: effects of amino acid antagonists.大鼠小脑环磷酸鸟苷（cGMP）水平的刺激：氨基酸拮抗剂的作用

Br J Pharmacol. 1981 Nov;74(3):723-9. doi: 10.1111/j.1476-5381.1981.tb10484.x.

Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative.HA-966（3-氨基-1-羟基吡咯烷-2-酮）的对映体表现出不同的中枢神经系统效应：（+）-HA-966是一种选择性甘氨酸/N-甲基-D-天冬氨酸受体拮抗剂，而（-）-HA-966是一种强效的γ-丁内酯样镇静剂。

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