甲状腺素抑制疗法治疗良性、无功能的孤立性甲状腺结节：一项质量效应荟萃分析。
Thyroxine suppression therapy for benign, non-functioning solitary thyroid nodules: a quality-effects meta-analysis.
作者信息
Yousef Altayyeb, Clark Justin, Doi Suhail A R
机构信息
Department of Medicine, Mubarak Al-Kabeer Teaching Hospital, Kuwait.
出版信息
Clin Med Res. 2010 Dec;8(3-4):150-8. doi: 10.3121/cmr.2010.881. Epub 2010 Aug 25.
Abstract
Levothyroxine (LT4) suppressive therapy for solitary thyroid nodules is not popularly advocated presently because its clinical efficacy and safety are currently considered controversial. This meta-analysis aims to address efficacy issues by using rigorous methods to arrive at a pooled estimate. On the basis of the analysis, it is estimated that LT4 therapy is clearly associated with up to a two-fold increase in the chance of nodule reduction. This translates to a number needed to treat (NNT) of 6 or a 50% decrease in the risk of cancer given nodule reduction. Keeping this definition of efficacy in mind and a low incidence of adverse events with low level LT4 suppression, such an intervention might be appropriate in patients selected on the basis of a low risk for adverse effects.
摘要
目前，左甲状腺素（LT4）抑制疗法用于治疗孤立性甲状腺结节并不被广泛提倡，因为其临床疗效和安全性目前存在争议。这项荟萃分析旨在通过严谨的方法得出汇总估计值，以解决疗效问题。基于该分析，估计LT4疗法与结节缩小几率增加高达两倍明显相关。这意味着治疗所需人数（NNT）为6，或者在结节缩小的情况下癌症风险降低50%。牢记这种疗效定义以及低剂量LT4抑制时不良事件发生率较低的情况，对于根据不良反应低风险选择的患者，这种干预可能是合适的。
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