Zillikens D, Miller K, Hartmann A A, Burg G
Department of Dermatology, University of Würzburg, FRG.
Dermatologica. 1990;181(4):304-7. doi: 10.1159/000247833.
An 84-year-old male with a 4-week history of vesiculobullous eruptions was diagnosed clinically and pathologically to suffer from pemphigus foliaceus. Amazingly, direct immunofluorescence demonstrated intercellular IgA deposits in the whole epidermis. The patient did not respond to a regimen of fluocortolone and azathioprine but rapidly improved under dapsone. The few reported dermatoses with intraepidermal IgA deposits do not form a homogeneous group. In the following, their spectrum will be outlined. It is important to distinguish these dermatoses from IgG pemphigus, since they require a different therapy.
一名84岁男性，有4周的水疱大疱性皮疹病史，经临床和病理诊断为落叶型天疱疮。令人惊讶的是，直接免疫荧光显示整个表皮有细胞间IgA沉积。患者对氟可的龙和硫唑嘌呤治疗方案无反应，但在氨苯砜治疗下迅速好转。少数报道的有表皮内IgA沉积的皮肤病并不构成一个同质的群体。以下将概述它们的范围。将这些皮肤病与IgG天疱疮区分开来很重要，因为它们需要不同的治疗方法。
