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伽玛刀放射外科治疗前庭神经鞘瘤后出现正常压力脑积水。

Normal pressure hydrocephalus after gamma knife radiosurgery for vestibular schwannoma.

作者信息

Mohammed T A, Ahuja M S, Ju S S, Thomas J

机构信息

Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore.

出版信息

J Postgrad Med. 2010 Jul-Sep;56(3):213-5. doi: 10.4103/0022-3859.68634.

Abstract

Vestibular schwannomas are not uncommon, and gamma knife radiosurgery is one of the treatment options for symptomatic tumors. Hydrocephalus is a complication of gamma knife treatment of vestibular schwannoma, though the mechanism of the development of hydrocephalus remains controversial. We present an unusual case of normal pressure hydrocephalus (NPH) after gamma knife radiosurgery of a vestibular schwannoma in which the timeline of events strongly suggests that gamma knife played a contributory role in the development of the hydrocephalus. This is probably the first case of NPH post radiosurgery with normal cerebrospinal fluid protein. Communicating hydrocephalus should be treated with placement of shunt while non-communicating hydrocephalus can be treated with third ventriculostomy. Frequent monitoring and early intervention post radiosurgery is highly recommended to prevent irreversible cerebral damage.

摘要

前庭神经鞘瘤并不罕见,伽玛刀放射外科手术是有症状肿瘤的治疗选择之一。脑积水是伽玛刀治疗前庭神经鞘瘤的一种并发症,尽管脑积水的发生机制仍存在争议。我们报告了一例前庭神经鞘瘤伽玛刀放射外科手术后发生正常压力脑积水(NPH)的不寻常病例,其中事件的时间线强烈表明伽玛刀在脑积水的发生中起了促成作用。这可能是首例脑脊液蛋白正常的放射外科手术后发生NPH的病例。交通性脑积水应通过放置分流管进行治疗,而非交通性脑积水可通过第三脑室造瘘术进行治疗。强烈建议在放射外科手术后进行频繁监测和早期干预,以防止不可逆转的脑损伤。

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