脂质在逆转录病毒复制中的作用。
The Role of Lipids in Retrovirus Replication.
作者信息
Waheed Abdul A, Freed Eric O
机构信息
Virus-Cell Interaction Section, HIV Drug Resistance Program, National Cancer Institute, Frederick, MD 21702, USA.
出版信息
Viruses. 2010 May 1;2(5):1146-1180. doi: 10.3390/v2051146.
Retroviruses undergo several critical steps to complete a replication cycle. These include the complex processes of virus entry, assembly, and budding that often take place at the plasma membrane of the host cell. Both virus entry and release involve membrane fusion/fission reactions between the viral envelopes and host cell membranes. Accumulating evidence indicates important roles for lipids and lipid microdomains in virus entry and egress. In this review, we outline the current understanding of the role of lipids and membrane microdomains in retroviral replication.
逆转录病毒要完成一个复制周期需经历几个关键步骤。这些步骤包括病毒进入、组装和出芽等复杂过程，这些过程通常发生在宿主细胞的质膜上。病毒的进入和释放都涉及病毒包膜与宿主细胞膜之间的膜融合/裂变反应。越来越多的证据表明脂质和脂质微区在病毒进入和释放过程中发挥着重要作用。在这篇综述中，我们概述了目前对脂质和膜微区在逆转录病毒复制中作用的理解。
Zotero 插件