Hara Fumikata, Kiyoto Sachiko, Takabatake Daisuke, Takashima Seiki, Aogi Kenjiro, Ohsumi Shozo, Teramoto Norihiro, Nishimura Rieko, Takashima Shigemitsu
Department of Breast Oncology, National Hospital Organization Shikoku Cancer Center, Matsuyama, Ehime, Japan.
Case Rep Oncol. 2010 Apr 29;3(2):142-147. doi: 10.1159/000313923.
Breast cancer metastases to the stomach are very rare. As characteristics of breast cancer metastases to the stomach, metastases of lobular carcinoma, mainly with signet ring cells, are frequently observed, and they are often difficult to distinguish from a primary gastric cancer with signet ring cells. Moreover, because no characteristic symptoms are shown and they involve a submucosal lesion, it is difficult to make a radiographic diagnosis. However, if a gastric lesion is observed after breast carcinoma surgery, differentiation between a gastric primary lesion and a metastatic lesion is very important in order to determine treatment. We encountered a case that was diagnosed as early gastric cancer discovered using an endoscope 2 years after surgery and which was found to be breast cancer metastasis to the stomach by gross cystic disease fluid protein (GCDFP) and cytokeratin (CK) 7/20 immunostaining of the biopsy tissue. Here, we report our findings of this unique case.
乳腺癌转移至胃非常罕见。作为乳腺癌转移至胃的特征，小叶癌转移，主要是印戒细胞型，经常可见，并且它们常常难以与原发性印戒细胞型胃癌相区分。此外，由于没有特征性症状且病变累及黏膜下，因此很难做出影像学诊断。然而，如果在乳腺癌手术后发现胃部病变，区分胃部原发性病变和转移性病变对于确定治疗方案非常重要。我们遇到一例患者，术后2年经内镜检查诊断为早期胃癌，经活检组织的总囊性病液蛋白（GCDFP）和细胞角蛋白（CK）7/20免疫染色发现是乳腺癌转移至胃。在此，我们报告这一独特病例的研究结果。
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