National Toxicology Program, NIEHS/NIH, Research Triangle Park, North Carolina 27709, USA.
Environ Mol Mutagen. 2010 Oct-Dec;51(8-9):774-80. doi: 10.1002/em.20607.
This manuscript presents an overview of a symposium held at the 2009 annual meeting of the Environmental Mutagen Society (EMS) in St. Louis, MO. The symposium was sponsored by the Women in the Environmental Mutagen Society (WEMS) special interest group, and it covered current molecular genetics technologies and their impact on diagnosis and treatment of diseases that primarily or differentially affect women. Four speakers presented groundbreaking new information from such areas as cancer genetics, gene-environment interactions, epigenetics, DNA repair, and molecular epidemiology. Although cancer was a primary focus of the symposium, other health issues such as obesity and cardiovascular disease were addressed. The rapid evolution in genomic technologies discussed in this symposium should provide new tools to explore some of the critical questions raised by the research projects described in this article. This symposium demonstrates that EMS provides a forum for the presentation, discussion, and extension of the data generated by the investigators featured in this article and other researchers engaged in the study of the molecular mechanisms and gene-environment interactions that impact women's health.
本文概述了在密苏里州圣路易斯举行的 2009 年环境诱变剂学会(EMS)年会上的一次研讨会。该研讨会由环境诱变剂学会中的女性特别兴趣小组(WEMS)赞助,涵盖了当前的分子遗传学技术及其对主要或差异影响女性的疾病的诊断和治疗的影响。四位演讲者介绍了癌症遗传学、基因-环境相互作用、表观遗传学、DNA 修复和分子流行病学等领域的开创性新信息。尽管癌症是研讨会的主要焦点,但也涉及了肥胖和心血管疾病等其他健康问题。本次研讨会讨论的基因组技术的快速发展应该为探索本文所述研究项目提出的一些关键问题提供新的工具。本次研讨会表明,EMS 为本文所述研究人员和其他从事影响女性健康的分子机制和基因-环境相互作用研究的研究人员所产生的数据的呈现、讨论和扩展提供了一个论坛。