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Alterations of microRNAs and their targets are associated with acquired resistance of MCF-7 breast cancer cells to cisplatin.miRNAs 及其靶标的改变与 MCF-7 乳腺癌细胞对顺铂获得性耐药有关。
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Longitudinal changes in PON1 enzymatic activities in Mexican-American mothers and children with different genotypes and haplotypes.墨西哥裔美国母亲及其不同基因型和单倍型的儿童体内 PON1 酶活性的纵向变化。
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Hypomethylation and genome instability in the germline of exposed parents and their progeny is associated with altered miRNA expression.暴露于环境因素的父母及其后代的生殖细胞中存在低甲基化和基因组不稳定性,这与 miRNA 表达的改变有关。
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C-reactive protein as a risk factor for coronary heart disease: a systematic review and meta-analyses for the U.S. Preventive Services Task Force.C反应蛋白作为冠心病的一个危险因素:美国预防服务工作组的系统评价和荟萃分析
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A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2.一项全基因组关联研究在9号染色体短臂22.2区域发现了一个新的卵巢癌易感位点。
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PALB2 functionally connects the breast cancer susceptibility proteins BRCA1 and BRCA2.PALB2在功能上连接乳腺癌易感蛋白BRCA1和BRCA2。
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Single nucleotide polymorphisms in the TP53 region and susceptibility to invasive epithelial ovarian cancer.TP53区域的单核苷酸多态性与侵袭性上皮性卵巢癌易感性
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遗传学与女性健康问题——欧洲分子生物学组织对女性科学家及与性别相关疾病议题的承诺。

Genetics and women's health issues--the commitment of EMS to women scientists and gender-associated disease topics.

机构信息

National Toxicology Program, NIEHS/NIH, Research Triangle Park, North Carolina 27709, USA.

出版信息

Environ Mol Mutagen. 2010 Oct-Dec;51(8-9):774-80. doi: 10.1002/em.20607.

DOI:10.1002/em.20607
PMID:20740639
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4936393/
Abstract

This manuscript presents an overview of a symposium held at the 2009 annual meeting of the Environmental Mutagen Society (EMS) in St. Louis, MO. The symposium was sponsored by the Women in the Environmental Mutagen Society (WEMS) special interest group, and it covered current molecular genetics technologies and their impact on diagnosis and treatment of diseases that primarily or differentially affect women. Four speakers presented groundbreaking new information from such areas as cancer genetics, gene-environment interactions, epigenetics, DNA repair, and molecular epidemiology. Although cancer was a primary focus of the symposium, other health issues such as obesity and cardiovascular disease were addressed. The rapid evolution in genomic technologies discussed in this symposium should provide new tools to explore some of the critical questions raised by the research projects described in this article. This symposium demonstrates that EMS provides a forum for the presentation, discussion, and extension of the data generated by the investigators featured in this article and other researchers engaged in the study of the molecular mechanisms and gene-environment interactions that impact women's health.

摘要

本文概述了在密苏里州圣路易斯举行的 2009 年环境诱变剂学会(EMS)年会上的一次研讨会。该研讨会由环境诱变剂学会中的女性特别兴趣小组(WEMS)赞助,涵盖了当前的分子遗传学技术及其对主要或差异影响女性的疾病的诊断和治疗的影响。四位演讲者介绍了癌症遗传学、基因-环境相互作用、表观遗传学、DNA 修复和分子流行病学等领域的开创性新信息。尽管癌症是研讨会的主要焦点,但也涉及了肥胖和心血管疾病等其他健康问题。本次研讨会讨论的基因组技术的快速发展应该为探索本文所述研究项目提出的一些关键问题提供新的工具。本次研讨会表明,EMS 为本文所述研究人员和其他从事影响女性健康的分子机制和基因-环境相互作用研究的研究人员所产生的数据的呈现、讨论和扩展提供了一个论坛。