Gänger H, Nachbur B, Ris H B, Zurbrügg H
Universitätsklinik für Thorax-, Herz- und Gefässchirurgie, Inselspital Bern.
Helv Chir Acta. 1990 Oct;57(2):213-7.
The results of a retrospective study comparing two equally large groups of patients treated either surgically for restoration of venous patency and valvular function (24 patients) or medically with heparine, oral anticoagulants and compression stockings (25 patients) are presented. Follow-up time was 7.6 and 7.9 years respectively, operative mortality nil. Assessment of venous function was based on clinical observations as well as on measurements of haemodynamic parameters. Non-fatal pulmonary embolism after onset of treatment occurred in both cohorts with an equal frequency of 13%. Patients operated on for ilio-femoral deep venous thrombosis (DVT) were with few exceptions totally independent of any form of adjunctive hosiery which was in sharp contrast to the conservatively managed group. If onset of DVT had occurred more than three days earlier and extended from the ilio-femoral axis to the popliteo-crural level, surgery usually failed and patients were no better off than in the comparable medical subgroup. The same pattern of late outcome was found for all other clinical and haemodynamic parameters; i.e. clinical signs of venous hypertension, valvular competence as judged by sonography, patient's self-assessment and the expelled volume and refilling time measured by dynamic plethysmography after standardized leg-work. The mean expelled volume was 1.1 +/- 0.5 ml/100 g/min for the surgical subgroup treated early for ilio-femoral DVT and 0.7 +/- 0.5/100 g/min for the corresponding medical group (p = 0.05). Recovery or refilling time was 50 +/- 21 sec for the surgical group and 28 +/- 26 sec for the medical group (p = 0.03).(ABSTRACT TRUNCATED AT 250 WORDS)
本文呈现了一项回顾性研究的结果,该研究比较了两组规模相同的患者。一组(24例患者)接受手术治疗以恢复静脉通畅和瓣膜功能,另一组(25例患者)接受药物治疗,包括使用肝素、口服抗凝剂和弹力袜。随访时间分别为7.6年和7.9年,手术死亡率为零。静脉功能评估基于临床观察以及血流动力学参数测量。两组治疗后非致命性肺栓塞的发生率相同,均为13%。接受髂股深静脉血栓形成(DVT)手术的患者,除少数例外,完全无需任何形式的辅助袜具,这与保守治疗组形成鲜明对比。如果DVT发作超过三天且从髂股轴延伸至腘-小腿水平,手术通常会失败,患者的情况并不比相应的药物治疗亚组更好。所有其他临床和血流动力学参数的晚期结果模式相同;即静脉高压的临床体征、超声判断的瓣膜功能、患者的自我评估以及标准化腿部运动后动态体积描记法测量的排出量和再充盈时间。早期接受髂股DVT手术治疗的亚组平均排出量为1.1±0.5 ml/100 g/min,相应药物治疗组为0.7±0.5/100 g/min(p = 0.05)。手术组的恢复或再充盈时间为50±21秒,药物治疗组为28±26秒(p = 0.03)。(摘要截取自250字)