Gruber H E, Lachman R S, Rimoin D L
Medical Genetics-Birth Defects Center, Cedars-Sinai Medical Center, Los Angeles, CA 90048.
J Anat. 1990 Dec;173:69-75.
Knowledge of the structure of cartilage vascular canals is important for a more thorough understanding of the development of cartilage and the growth plate in the human neonate and growing child. We have studied the costochondral junction of 6 normal neonates and 12 normal children (age 4 months-16 years) and utilised quantitative histomorphometry to define the percentage tissue area occupied by canals and the number of canals/mm2. Both percentage canal area and the number of canals/mm2 were significantly greater in newborn vs. older children (percentage area: 0.42 +/- 0.15 (mean +/- S.E.M.) vs. 0.08 +/- 0.04, P = 0.003; number/mm2: 0.2 +/- 0.09 vs. 0.04 +/- 0.02, P = 0.02). Eight newborn patients with achondrogenesis II-hypochondrogenesis were also studied. Both percentage canal area and number were significantly elevated above normal (percentage area: 5.22 +/- 1.01, P less than 0.001; number/mm2: 1.45 +/- 0.26, P less than 0.001). Results presented here demonstrate that: (i) quantitative differences in vascular canal area and numbers occur during development; (ii) 10-fold increases in vascular canal area and number are present in achondrogenesis II-hypochondrogenesis. Data from normal subjects will provide normative values against which vascular abnormalities in other skeletal dysplasias can be compared.
了解软骨血管通道的结构对于更深入地理解人类新生儿和成长中儿童的软骨及生长板发育至关重要。我们研究了6例正常新生儿和12例正常儿童（年龄4个月至16岁）的肋软骨连接，并采用定量组织形态计量学来确定通道所占组织面积的百分比以及每平方毫米通道的数量。新生儿的通道面积百分比和每平方毫米通道数量均显著高于大龄儿童（面积百分比：0.42±0.15（均值±标准误）对0.08±0.04，P = 0.003；每平方毫米数量：0.2±0.09对0.04±0.02，P = 0.02）。还研究了8例Ⅱ型软骨生成不全-低软骨生成不全的新生儿患者。通道面积百分比和数量均显著高于正常水平（面积百分比：5.22±1.01，P＜0.001；每平方毫米数量：1.45±0.26，P＜0.001）。此处呈现的结果表明：（i）发育过程中血管通道面积和数量存在定量差异；（ii）Ⅱ型软骨生成不全-低软骨生成不全中血管通道面积和数量增加了10倍。来自正常受试者的数据将提供标准值，可用于比较其他骨骼发育异常中的血管异常情况。
