Gruber H E, Rimoin D L
Medical Genetics-Birth Defects Center, Cedars-Sinai Medical Center, Los Angeles, California 90048.
Pediatr Res. 1989 Feb;25(2):202-4. doi: 10.1203/00006450-198902000-00024.
The mean number of cells per cartilage column and the proportion of hypertrophic and proliferative chondrocytes per column were determined in the costochondral junction in a population of normal subjects including 10 fetal-newborns and 15 subjects aged 0.3-16 y of age. Both the mean number of cells per column and the proportion of proliferative cells per column were significantly greater in the fetal-newborn population compared to the pediatric population (12.6 +/- 1.0 versus 8.4 +/- 0.4, p less than 0.001 and 39.6 +/- 6.9 versus 24.4 +/- 2.5, p = 0.025, respectively) (mean +/- sem [n]). The number of cells per column bore a significant negative relationship to subject age (r = -0.52, p = 0.007). Significant positive correlations were found between the mean number of cells per column and age-specific growth velocity both in males (length-height velocity = [(6.3) (mean number of cells) - 44.1], r = 0.72, p = 0.02) and in females (length-height velocity = [(3.4 (mean number of cells) - 14.4], r = 0.77, p = 0.006). These data will provide normative values against which abnormalities characteristic of the skeletal dysplasias can be compared.
在包括10名胎儿-新生儿和15名0.3 - 16岁受试者的正常人群的肋软骨交界处，测定了每个软骨柱的平均细胞数以及每个柱中肥大和增殖软骨细胞的比例。与儿童人群相比，胎儿-新生儿人群中每个柱的平均细胞数和每个柱中增殖细胞的比例均显著更高（分别为12.6±1.0对8.4±0.4，p<0.001；39.6±6.9对24.4±2.5，p = 0.025）（平均值±标准误[n]）。每个柱的细胞数与受试者年龄呈显著负相关（r = -0.52，p = 0.007）。在男性（身长-身高速度=[(6.3)(平均细胞数)-44.1]，r = 0.72，p = 0.02）和女性（身长-身高速度=[(3.4(平均细胞数)-14.4]，r = 0.77，p = 0.006）中，每个柱的平均细胞数与年龄特异性生长速度之间均发现显著正相关。这些数据将提供标准值，可据此比较骨骼发育异常的特征。
