Topchieva I N, Erokhin V N, Burlakova E B, Khrutskaia M M, Kupriianova T A, Bykovskaia S Iu
Izv Akad Nauk SSSR Biol. 1990 Nov-Dec(6):918-24.
Influence of block copolymers of ethylene and propylene oxides (proxanols) on the human natural killer activity was studied. Proxanols had no effect on the lymphocytes viability and increased their cytotoxic activity against target cells K 562 in vitro. Certain antitumor properties of proxanols were demonstrated in vivo (especially for ascitic tumors). The proxanols activity was chiefly determined by the membranotropic properties of its main polymer chain.
研究了环氧乙烷和环氧丙烷的嵌段共聚物（聚醚醇）对人类自然杀伤活性的影响。聚醚醇对淋巴细胞活力没有影响，并且在体外增强了它们对靶细胞K562的细胞毒性活性。聚醚醇的某些抗肿瘤特性在体内得到了证实（尤其是对腹水肿瘤）。聚醚醇的活性主要由其主聚合物链的膜亲和特性决定。
