Okutomi T, Inagawa H, Nishizawa T, Oshima H, Soma G, Mizuno D
Biotechnology Research Center, Teikyo University, Kanagawa, Japan.
J Biol Response Mod. 1990 Dec;9(6):564-9.
Orally administered muramyl dipeptide (MDP) was found to prime induction of endogenous tumor necrosis factor (TNF) in mice. This priming effect was observed after oral administration of MDP of more than 100 micrograms/mouse; the maximal time interval between oral administration of MDP and i.v. injection of OK-432, a triggering agent for induction of endogenous TNF, was extended over 3-10 h and then decreased after 24 h. Antitumor effect against Meth-A, MH134, and MM46 tumor cells in mice was observed after oral administration of MDP followed by i.v. injection of OK-432. These findings suggest that orally administered MDP can be used as a priming agent for inducing endogenous TNF in cancer patients, and that MDP, a component of enteric bacteria, must have an important role in maintaining homeostasis through activation of macrophages.
经口服给予的胞壁酰二肽（MDP）被发现可引发小鼠体内内源性肿瘤坏死因子（TNF）的诱导。在口服超过100微克/只小鼠的MDP后观察到这种引发效应；口服MDP与静脉注射OK-432（一种诱导内源性TNF的触发剂）之间的最大时间间隔延长至3至10小时，然后在24小时后下降。在口服MDP后再静脉注射OK-432，观察到对小鼠体内Meth-A、MH134和MM46肿瘤细胞的抗肿瘤作用。这些发现表明，口服给予的MDP可用作诱导癌症患者体内内源性TNF的引发剂，并且作为肠道细菌成分的MDP必定在通过激活巨噬细胞维持体内平衡方面发挥重要作用。
